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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?

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By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

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Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

HAZET 759N-2VDE 251 mm Universal Pliers with Predective Insulation - Multi-Co...Hazet 9021P-2-012 3 Ratchet HousingHD 3500 LB GEAR HAND TRAILER CABLE WINCH BOAT TRAILER AUTO MARINEHeavy Duty 12 14 18 Inch Straight Handle Pipe Wrench Treated Adjustable Quality Continue reading “Restrictive versus Liberal Fluid Therapy in Abdominal Surgery”

Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Grip On Tools - Bulk Lot - Wrench, Pliers, Paint Brush, Scissors, Tape, Stool. Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

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By Martina McGrath, MD
July 18, 2018

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Draperie 383-j2 19mm-60mm Pince À Circlips Interne Droite Elora, 19 - blue, J2 lhilwq1290-Pliers

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Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

Her Hardware 38200 Project & Repair Tool Set

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

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By Martina McGrath, MD
June 5, 2018

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Diesel Engine Compression Master Test Kit 4510 Laser

By Lea Borgi, MD
May 16, 2018

Diesel Injector Removal Set - Delphi Bosch 4760 LaserDigging Bar Hardened Steel Mushroom Tamper Head And Wide Digging Blade 1700mmDigital Torque Wrench 1 4 D 5167 Laser Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”